Rheumatoid factor and Fc signaling: A tale of two Cinderellas

N. R.St C. Sinclair, A. Panoskaltsis

Research output: Contribution to journalShort surveypeer-review

19 Scopus citations


Signaling to lymphocytes depends not only upon the interaction of receptors with specific antigen, but also upon antigen nonspecific receptors which receive input from two classes of molecules, immunologically specific end products and lymphokines. These represent the central elements in the physiologic stimulation of immune responses to both self and foreign antigens. This review is dedicated primarily to describing the function of physiologically active receptors for end product which are central to end product feedback in normal immune responses. The emergence of autoimmunity as a pathologic process resultant from a defective end product signaling mechanism is described.

Original languageEnglish (US)
Pages (from-to)133-146
Number of pages14
JournalClinical Immunology and Immunopathology
Issue number2
StatePublished - Aug 1989
Externally publishedYes

Bibliographical note

Funding Information:
This work is supported by the Arthritis Society of Canada. We acknowledge, Raymond C. Raymond family for personal support of one of us (A.P.).

Copyright 2018 Elsevier B.V., All rights reserved.


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