Rhabdomyosarcomagenesis - Novel pathway found

Atsushi Asakura; Michael A. Rudnicki

doi:10.1016/S1535-6108(03)00313-1

Rhabdomyosarcomagenesis - Novel pathway found

Atsushi Asakura, Michael A. Rudnicki

Neurology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Recent work presented in this issue of Cancer Cell by Fleischmann et al. on gene knockout mice revealed a remarkable molecular pathway for rhabdomyosarcomagenesis, in which Trp53/Fos double mutant mice developed RMS of the facial and orbital regions with high penetrance. This finding may provide novel molecular mechanisms for Rhabdomyosarcomagenesis and therapeutic implications for RMS patients.

Original language	English (US)
Pages (from-to)	421-422
Number of pages	2
Journal	Cancer Cell
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/S1535-6108(03)00313-1
State	Published - Dec 2003

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title = "Rhabdomyosarcomagenesis - Novel pathway found",

abstract = "Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Recent work presented in this issue of Cancer Cell by Fleischmann et al. on gene knockout mice revealed a remarkable molecular pathway for rhabdomyosarcomagenesis, in which Trp53/Fos double mutant mice developed RMS of the facial and orbital regions with high penetrance. This finding may provide novel molecular mechanisms for Rhabdomyosarcomagenesis and therapeutic implications for RMS patients.",

author = "Atsushi Asakura and Rudnicki, {Michael A.}",

year = "2003",

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AU - Asakura, Atsushi

AU - Rudnicki, Michael A.

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AB - Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Recent work presented in this issue of Cancer Cell by Fleischmann et al. on gene knockout mice revealed a remarkable molecular pathway for rhabdomyosarcomagenesis, in which Trp53/Fos double mutant mice developed RMS of the facial and orbital regions with high penetrance. This finding may provide novel molecular mechanisms for Rhabdomyosarcomagenesis and therapeutic implications for RMS patients.

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DO - 10.1016/S1535-6108(03)00313-1

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JO - Cancer Cell

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ER -

Rhabdomyosarcomagenesis - Novel pathway found

Abstract

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