Rhabdomyosarcomagenesis - Novel pathway found

Atsushi Asakura, Michael A. Rudnicki

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Recent work presented in this issue of Cancer Cell by Fleischmann et al. on gene knockout mice revealed a remarkable molecular pathway for rhabdomyosarcomagenesis, in which Trp53/Fos double mutant mice developed RMS of the facial and orbital regions with high penetrance. This finding may provide novel molecular mechanisms for Rhabdomyosarcomagenesis and therapeutic implications for RMS patients.

Original languageEnglish (US)
Pages (from-to)421-422
Number of pages2
JournalCancer Cell
Volume4
Issue number6
DOIs
StatePublished - Dec 2003

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