RGS6/Gβ5 complex accelerates I_KACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate

Biochemistry, Genetics and Molecular Biology

• Signal Transduction 100%
• Immunoprecipitation 100%
• Signaling Protein 100%
• RGS6 100%
• Gene Targeting 100%
• Electrocardiogram 100%
• Whole Cell Patch Clamp 100%
• Heterotrimeric G Protein 100%
• Cardiac Muscle Cell 100%
• Muscarinic Acetylcholine Receptor 100%
• Potassium Channel 100%
• Pertussis Toxin 100%
• Immunoblotting 100%
• G Protein 100%

Keyphrases

• Heart Rate 100%
• Gating Kinetics 100%
• Atrial Myocytes 100%
• IKACh 100%
• RGS6 100%
• Parasympathetic Regulation 100%
• Molecular Mechanism 20%
• Gene Targeting 20%
• Bradycardia 20%
• Potassium Channel 20%
• Ablation 20%
• G Protein 20%
• G Protein Signaling 20%
• Signal Transduction Pathway 20%
• Muscarinic Cholinergic Receptor 20%
• Cardiac Physiology 20%
• Heart Rate Response 20%
• Single-unit Recording 20%
• Immunoblotting 20%
• Pertussis Toxin 20%
• Cardiac Effects 20%
• Pharmacological Manipulation 20%
• Deactivation Kinetics 20%
• Isolated Cardiomyocytes 20%
• Sequential Activation 20%
• Sinoatrial Nodal Cells 20%
• ECG Telemetry 20%
• Co-immunoprecipitation (co-IP) 20%
• Critical Signals 20%

Medicine and Dentistry

• Guanine Nucleotide Binding Protein 100%
• Gene Targeting 50%
• Electrocardiogram 50%
• Signal Transduction Pathway 50%
• Muscarinic Acetylcholine Receptor 50%
• Cardiac Physiology 50%
• Immunoprecipitation 50%
• Isolated Cardiomyocyte 50%
• Potassium Channel 50%
• Immunoblotting 50%
• Pertussis Toxin 50%
• Whole Cell 50%