Abstract
Background: RGS4 and RGS6 are regulator ofGprotein signaling (RGS) proteins, and both have been proposed to modulate parasympathetic regulation of heart rate (HR). Results: RGS6 ablation enhances parasympathetic influence on the heart; RGS4 ablation does not. Conclusion: RGS6 is the primary RGS modulator of parasympathetic influence on the heart. Significance: Understanding the parasympathetic regulation of HR will improve treatment of arrhythmias.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2440-2449 |
| Number of pages | 10 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 24 2014 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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