RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

Nicole Wydeven, Ekaterina Posokhova, Zhilian Xia, Kirill A. Martemyanov, Kevin Wickman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background: RGS4 and RGS6 are regulator ofGprotein signaling (RGS) proteins, and both have been proposed to modulate parasympathetic regulation of heart rate (HR). Results: RGS6 ablation enhances parasympathetic influence on the heart; RGS4 ablation does not. Conclusion: RGS6 is the primary RGS modulator of parasympathetic influence on the heart. Significance: Understanding the parasympathetic regulation of HR will improve treatment of arrhythmias.

Original languageEnglish (US)
Pages (from-to)2440-2449
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - Jan 24 2014

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