TY - JOUR
T1 - RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate
AU - Wydeven, Nicole
AU - Posokhova, Ekaterina
AU - Xia, Zhilian
AU - Martemyanov, Kirill A.
AU - Wickman, Kevin
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: RGS4 and RGS6 are regulator ofGprotein signaling (RGS) proteins, and both have been proposed to modulate parasympathetic regulation of heart rate (HR). Results: RGS6 ablation enhances parasympathetic influence on the heart; RGS4 ablation does not. Conclusion: RGS6 is the primary RGS modulator of parasympathetic influence on the heart. Significance: Understanding the parasympathetic regulation of HR will improve treatment of arrhythmias.
AB - Background: RGS4 and RGS6 are regulator ofGprotein signaling (RGS) proteins, and both have been proposed to modulate parasympathetic regulation of heart rate (HR). Results: RGS6 ablation enhances parasympathetic influence on the heart; RGS4 ablation does not. Conclusion: RGS6 is the primary RGS modulator of parasympathetic influence on the heart. Significance: Understanding the parasympathetic regulation of HR will improve treatment of arrhythmias.
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U2 - 10.1074/jbc.M113.520742
DO - 10.1074/jbc.M113.520742
M3 - Article
C2 - 24318880
AN - SCOPUS:84893098826
SN - 0021-9258
VL - 289
SP - 2440
EP - 2449
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 4
ER -
