Revolutionizing cardiovascular medicine: Targeted therapies for the cardiac conduction system

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Abstract

Arrhythmogenic cardiovascular disorders are associated with considerable morbidity and mortality. Whether cardiac conduction disease is caused by genetic defects, procedural perturbations, valvular disease, ischemia, aging, or heart failure, new therapies are warranted. In this issue of the JCI, Goodyer et al. used state-of-The-Art technologies to image the cardiac conduction system (CCS) in real time and to deliver targeted therapies to the CCS and its subcomponents. These findings advance the ability to image and treat specific lineages within the adult heart with the potential for broader applications in the treatment of cardiovascular diseases.

Original languageEnglish (US)
Article numbere164192
JournalJournal of Clinical Investigation
Volume132
Issue number20
DOIs
StatePublished - Oct 17 2022

Bibliographical note

Funding Information:
This work is supported in part by grants from the NIH (HL148599, HL160476, and P01HL160476), Regenerative Medicine Minnesota (101617-DS-003), and the US Department of Defense (DOD W81XWH). We would like to acknowledge the assistance of Cynthia Faraday for the figure concept.

Publisher Copyright:
© 2022 American Society for Clinical Investigation. All rights reserved.

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