Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance

Keyphrases

• Folate 100%
• Antifolate 100%
• Folate Biosynthesis 100%
• Biosynthesis Pathway 50%
• Amino Acids 25%
• Microbes 25%
• Antimicrobial 25%
• Drug Target 25%
• Prokaryotes 25%
• Methionine 25%
• Eukaryotes 25%
• Purine 25%
• Glycine 25%
• Growing Cells 25%
• Coenzyme A 25%
• Commensal Microbiota 25%
• Transfer RNA (tRNA) 25%
• Utilization Pathways 25%
• Thymidine 25%
• One-carbon 25%
• Vitamin B9 25%
• Proton-coupled Folate Transporter 25%
• Metabolic Cofactors 25%
• Cancer Chemotherapeutics 25%
• Antifolate Drugs 25%
• Carbon Carrier 25%

Immunology and Microbiology

• Susceptibility 100%
• Eukaryote 50%
• Microflora 50%
• Prokaryote 50%
• Coenzyme 50%
• Amino Acid 50%
• Methionine 50%
• Serine 50%
• Transfer RNA 50%

Biochemistry, Genetics and Molecular Biology

• Folic Acid 100%
• Antifolate 100%
• Anabolism 50%
• Amino Acids 12%
• Eukaryote 12%
• Microflora 12%
• Serine 12%
• Prokaryote 12%
• Methionine 12%
• Transfer RNA 12%
• Coenzyme A 12%
• Thymidine 12%