Revitalization of the AA and ANA rat lines: Effects on some line characteristics

L. Hilakivi, C. J.P. Eriksson, M. Sarviharju, J. D. Sinclair

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


After 37 generations, the AA and ANA rat lines developed for high and low voluntary alcohol consumption, were revitalized by crossing with hybrid (Brown Norwegian X Lewis) rats. The line difference in alcohol consumption continued, although initially diminished, after revitalization. The greater acetaldehyde accumulation and longer loss of righting reflex after ethanol administration of the ANAs persisted after revitalization, but significant line differences in motor impairment were no longer found. The line characteristics for open-field test behavior were also different than before revitalization. Of the previously-observed line differences that have now been reexamined, the level of blood acetaldehyde during ethanol metabolism appears to be the most closely related to the genetically-determined factors influencing alcohol consumption.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
Issue number1
StatePublished - 1984
Externally publishedYes


  • Acetaldehyde
  • Blood alcohol concentration
  • Motor impairment
  • Narcosis
  • Open-field behavior
  • Selected rat lines
  • Voluntary alcohol consumption


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