Revisiting KDIGO clinical practice guideline on chronic kidney disease-mineral and bone disorder: A commentary from a Kidney Disease: Improving Global Outcomes controversies conference

Markus Ketteler, Grahame J. Elder, Pieter Evenepoel, Joachim H. Ix, Sophie A. Jamal, Marie Hélène Lafage-Proust, Rukshana Shroff, Ravi I. Thadhani, Marcello A. Tonelli, Bertram L. Kasiske, David C. Wheeler, Mary B. Leonard

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

A new definition and classification of chronic kidney disease-mineral and bone disorder (CKD-MBD) was proposed in 2005 and it was later followed by a guideline publication on this topic from Kidney Disease: Improving Global Outcomes (KDIGO) in 2009. This work recognized that CKD-MBD is a syndrome of bone abnormalities, laboratory abnormalities, and vascular calcification linked to fractures, cardiovascular disease, and mortality. Because of limited data at the time of the original guideline systematic review, many of the recommendations were cautiously vague. KDIGO convened a Controversies Conference in October 2013 to review the CKD-MBD literature published since the 2009 guideline. Specifically, the objective of this conference was to determine whether sufficient new data had emerged to support a reassessment of the CKD-MBD guideline and if so to determine the scope of these potential revisions. This report summarizes the results of these proceedings, highlighting important new studies conducted in the interval since the original KDIGO CKD-MBD guideline.

Original languageEnglish (US)
Pages (from-to)502-508
Number of pages7
JournalKidney international
Volume87
Issue number3
DOIs
StatePublished - Mar 1 2015

Bibliographical note

Publisher Copyright:
© 2014 International Society of Nephrology.

Keywords

  • CKD-MBD
  • PTH
  • calcium
  • clinical practice guideline
  • phosphate
  • renal osteodystrophy

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