Abstract
Numerous published case reports of IgA-related anaphylactic transfusion reactions (1968-present) alert us that certain IgA-deficient persons are at risk for acute generalized transfusion reactions, presenting with severe shortness of breath. However, such IgA anaphylactic transfusion reactions are uncommon, and the majority of clinical diagnoses are not confirmed by detection of anti-IgA in the patient's plasma. The recognition of other transfusion-related acute generalized reactions in recent years requires expanding the differential diagnosis for such events to include other possible diagnoses, most importantly TRALI. Clinical diagnoses of IgA anaphylactic transfusion reactions should be followed up promptly by testing for anti-IgA. Failure to follow up a clinical diagnosis by testing for anti-IgA will complicate management of any future blood transfusions and potentially commit the patient to a lifelong requirement for highly specialized IgA-deficient blood products.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 234-238 |
| Number of pages | 5 |
| Journal | Immunohematology |
| Volume | 20 |
| Issue number | 4 |
| State | Published - Dec 20 2004 |
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Review : IgA anaphylactic transfusion reactions. Part II. Clinical diagnosis and bedside management. / Sandler, S. Gerald; Zantek, Nicole Dodge.
In: Immunohematology, Vol. 20, No. 4, 20.12.2004, p. 234-238.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Review
T2 - IgA anaphylactic transfusion reactions. Part II. Clinical diagnosis and bedside management
AU - Sandler, S. Gerald
AU - Zantek, Nicole Dodge
PY - 2004/12/20
Y1 - 2004/12/20
N2 - Numerous published case reports of IgA-related anaphylactic transfusion reactions (1968-present) alert us that certain IgA-deficient persons are at risk for acute generalized transfusion reactions, presenting with severe shortness of breath. However, such IgA anaphylactic transfusion reactions are uncommon, and the majority of clinical diagnoses are not confirmed by detection of anti-IgA in the patient's plasma. The recognition of other transfusion-related acute generalized reactions in recent years requires expanding the differential diagnosis for such events to include other possible diagnoses, most importantly TRALI. Clinical diagnoses of IgA anaphylactic transfusion reactions should be followed up promptly by testing for anti-IgA. Failure to follow up a clinical diagnosis by testing for anti-IgA will complicate management of any future blood transfusions and potentially commit the patient to a lifelong requirement for highly specialized IgA-deficient blood products.
AB - Numerous published case reports of IgA-related anaphylactic transfusion reactions (1968-present) alert us that certain IgA-deficient persons are at risk for acute generalized transfusion reactions, presenting with severe shortness of breath. However, such IgA anaphylactic transfusion reactions are uncommon, and the majority of clinical diagnoses are not confirmed by detection of anti-IgA in the patient's plasma. The recognition of other transfusion-related acute generalized reactions in recent years requires expanding the differential diagnosis for such events to include other possible diagnoses, most importantly TRALI. Clinical diagnoses of IgA anaphylactic transfusion reactions should be followed up promptly by testing for anti-IgA. Failure to follow up a clinical diagnosis by testing for anti-IgA will complicate management of any future blood transfusions and potentially commit the patient to a lifelong requirement for highly specialized IgA-deficient blood products.
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UR - http://www.scopus.com/inward/citedby.url?scp=10044236509&partnerID=8YFLogxK
M3 - Review article
VL - 20
SP - 234
EP - 238
JO - Immunohematology / American Red Cross
JF - Immunohematology / American Red Cross
SN - 0894-203X
IS - 4
ER -