Review article: Lack of clinical significance of the interaction between H2‐receptor antagonists and ethanol

M. D. LEVITT

doi:10.1111/j.1365-2036.1993.tb00081.x

Review article: Lack of clinical significance of the interaction between H₂‐receptor antagonists and ethanol

M. D. LEVITT

Research output: Contribution to journal › Review article › peer-review

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Abstract

It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H₂‐receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H₂‐antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H₂‐antagonists and ethanol is clinically insignificant.

Original language	English (US)
Pages (from-to)	131-138
Number of pages	8
Journal	Alimentary Pharmacology & Therapeutics
Volume	7
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2036.1993.tb00081.x
State	Published - Apr 1993
Externally published	Yes

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10.1111/j.1365-2036.1993.tb00081.x

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title = "Review article: Lack of clinical significance of the interaction between H2‐receptor antagonists and ethanol",

abstract = "It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2‐receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2‐antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2‐antagonists and ethanol is clinically insignificant.",

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year = "1993",

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AU - LEVITT, M. D.

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N2 - It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2‐receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2‐antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2‐antagonists and ethanol is clinically insignificant.

AB - It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2‐receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2‐antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2‐antagonists and ethanol is clinically insignificant.

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ER -

Review article: Lack of clinical significance of the interaction between H₂‐receptor antagonists and ethanol

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