Reversible regulation of bioactive ligands presented on immobilized gold nanoparticles

Xintong Wang; Jeremiah J. Riesberg; Wei Shen

doi:10.1039/c2sm06567c

Reversible regulation of bioactive ligands presented on immobilized gold nanoparticles

Xintong Wang, Jeremiah J. Riesberg, Wei Shen

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A polypeptide fusion of a bioactive ligand and a coiled-coil A was functionalized on gold nanoparticles, which were subsequently immobilized on substrates. The accessibility of the ligand could be reversibly controlled via co-immobilization and removal of B-poly(ethylene) glycol through heterodimerization between A and the complementary coiled-coil B.

Original language	English (US)
Pages (from-to)	2812-2815
Number of pages	4
Journal	Soft Matter
Volume	8
Issue number	10
DOIs	https://doi.org/10.1039/c2sm06567c
State	Published - Mar 14 2012

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10.1039/c2sm06567c

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title = "Reversible regulation of bioactive ligands presented on immobilized gold nanoparticles",

abstract = "A polypeptide fusion of a bioactive ligand and a coiled-coil A was functionalized on gold nanoparticles, which were subsequently immobilized on substrates. The accessibility of the ligand could be reversibly controlled via co-immobilization and removal of B-poly(ethylene) glycol through heterodimerization between A and the complementary coiled-coil B.",

author = "Xintong Wang and Riesberg, {Jeremiah J.} and Wei Shen",

year = "2012",

month = mar,

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doi = "10.1039/c2sm06567c",

language = "English (US)",

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journal = "Soft Matter",

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publisher = "Royal Society of Chemistry",

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T1 - Reversible regulation of bioactive ligands presented on immobilized gold nanoparticles

AU - Wang, Xintong

AU - Riesberg, Jeremiah J.

AU - Shen, Wei

PY - 2012/3/14

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N2 - A polypeptide fusion of a bioactive ligand and a coiled-coil A was functionalized on gold nanoparticles, which were subsequently immobilized on substrates. The accessibility of the ligand could be reversibly controlled via co-immobilization and removal of B-poly(ethylene) glycol through heterodimerization between A and the complementary coiled-coil B.

AB - A polypeptide fusion of a bioactive ligand and a coiled-coil A was functionalized on gold nanoparticles, which were subsequently immobilized on substrates. The accessibility of the ligand could be reversibly controlled via co-immobilization and removal of B-poly(ethylene) glycol through heterodimerization between A and the complementary coiled-coil B.

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U2 - 10.1039/c2sm06567c

DO - 10.1039/c2sm06567c

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SP - 2812

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JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

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Reversible regulation of bioactive ligands presented on immobilized gold nanoparticles

Abstract

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