TY - JOUR
T1 - Reversible pancytopenia following OKT3
T2 - Use in the context of multidrug immunosuppression for kidney allografting
AU - Burke, George W.
AU - Vercellotti, Gregory M.
AU - Simmons, Richard L.
AU - Howe, Robert B.
AU - Canafax, Daniel M.
AU - Najarían, John S.
PY - 1989/9
Y1 - 1989/9
N2 - We present two instances of pancytopenia in kidney transplant patients associated with a course of OKT3 therapy. In one case, OKT3 was used prophylactically, in the other therapeutically to treat biopsy-proved rejection. They both occurred in the setting of multi-drug immunosuppression, including Minnesota anti-lymphocyte globulin, and recovered with supportive therapy. Previous antihypertensive medication, antibiotics, and azathioprine were restarted without hematologic sequelae. Evidence implicating OKT3, and resultant gamma-interferon—induced marrow suppression is discussed.
AB - We present two instances of pancytopenia in kidney transplant patients associated with a course of OKT3 therapy. In one case, OKT3 was used prophylactically, in the other therapeutically to treat biopsy-proved rejection. They both occurred in the setting of multi-drug immunosuppression, including Minnesota anti-lymphocyte globulin, and recovered with supportive therapy. Previous antihypertensive medication, antibiotics, and azathioprine were restarted without hematologic sequelae. Evidence implicating OKT3, and resultant gamma-interferon—induced marrow suppression is discussed.
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U2 - 10.1097/00007890-198909000-00010
DO - 10.1097/00007890-198909000-00010
M3 - Article
C2 - 2528849
AN - SCOPUS:0024456761
SN - 0041-1337
VL - 48
SP - 403
EP - 408
JO - Transplantation
JF - Transplantation
IS - 3
ER -