Reversible findings of restricted diffusion in 5-flourouracil neurotoxicity

L. T. Lucato, Alexander M McKinney, J. Short, M. Teksam, Chip Truwit

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26 Scopus citations


A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum. On discontinuing the medication, the areas of severely restricted diffusion had entirely resolved, with minimal residual T2 signal abnormality. In this case, immediate discontinuation of the chemotherapeutic agent apparently reversed the patient's symptoms and findings on MRI. The scant information available in the published literature regarding this phenomenon is reviewed with regard to 5-fluorouracil.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalAustralasian Radiology
Issue number4
StatePublished - Aug 1 2006


  • 5-fluorouracil
  • Brain diseases
  • Chemotherapy
  • Complication
  • Diffusion MRI
  • Magnetic resonance imaging


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