Reversible demyelinating neuropathy associated with renal cell carcinoma

Jeffrey A. Allen; Ximing J. Yang; Robert L. Sufit

doi:10.1016/j.nmd.2010.11.004

Reversible demyelinating neuropathy associated with renal cell carcinoma

Jeffrey A. Allen, Ximing J. Yang, Robert L. Sufit

Neurology

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8 Scopus citations

Abstract

Paraneoplastic neuropathy is a potential complication of renal cell carcinoma. The clinical and electrophysiologic features of such patients have not been well characterized. We describe a patient with a demyelinating neuropathy associated with papillary renal cell carcinoma that resolved following nephrectomy. The literature is reviewed with particular attention to the clinical, electrophysiologic, and kidney histopathologic characteristics of similar patients. Features arguing against other acquired demyelinating neuropathies are highlighted, and we conclude that abdominal imaging may provide important diagnostic data in some patients with evolving demyelinating neuropathies. The significance of papillary renal cell carcinoma (as opposed to clear renal cell carcinoma) is unknown, but may have important pathophysiologic implications.

Original language	English (US)
Pages (from-to)	227-231
Number of pages	5
Journal	Neuromuscular Disorders
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.nmd.2010.11.004
State	Published - Mar 2011

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

CIDP
Demyelinating
Electrophysiology
Neuropathy
Paraneoplastic

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10.1016/j.nmd.2010.11.004

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abstract = "Paraneoplastic neuropathy is a potential complication of renal cell carcinoma. The clinical and electrophysiologic features of such patients have not been well characterized. We describe a patient with a demyelinating neuropathy associated with papillary renal cell carcinoma that resolved following nephrectomy. The literature is reviewed with particular attention to the clinical, electrophysiologic, and kidney histopathologic characteristics of similar patients. Features arguing against other acquired demyelinating neuropathies are highlighted, and we conclude that abdominal imaging may provide important diagnostic data in some patients with evolving demyelinating neuropathies. The significance of papillary renal cell carcinoma (as opposed to clear renal cell carcinoma) is unknown, but may have important pathophysiologic implications.",

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author = "Allen, {Jeffrey A.} and Yang, {Ximing J.} and Sufit, {Robert L.}",

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T1 - Reversible demyelinating neuropathy associated with renal cell carcinoma

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AU - Yang, Ximing J.

AU - Sufit, Robert L.

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AB - Paraneoplastic neuropathy is a potential complication of renal cell carcinoma. The clinical and electrophysiologic features of such patients have not been well characterized. We describe a patient with a demyelinating neuropathy associated with papillary renal cell carcinoma that resolved following nephrectomy. The literature is reviewed with particular attention to the clinical, electrophysiologic, and kidney histopathologic characteristics of similar patients. Features arguing against other acquired demyelinating neuropathies are highlighted, and we conclude that abdominal imaging may provide important diagnostic data in some patients with evolving demyelinating neuropathies. The significance of papillary renal cell carcinoma (as opposed to clear renal cell carcinoma) is unknown, but may have important pathophysiologic implications.

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KW - Electrophysiology

KW - Neuropathy

KW - Paraneoplastic

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Reversible demyelinating neuropathy associated with renal cell carcinoma

Abstract

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Keywords

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