Reversible and irreversible damage of the myocardium: Ischemia/reperfusion injury and cardioprotection

Brian T. Howard, Tinen L Iles, James A. Coles, Daniel C. Sigg, Paul A Iaizzo

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Ischemia and reperfusion injuries can lead to major compromises in cardiac function. While the intent of many of the past cardioprotective therapies was to protect the myocardium from ischemic necrosis, it may be that reperfusion injury following ischemia may occur despite such preventative attempts. There are continued efforts to identify improvements in myocardial protective strategies (pre- and postconditioning), and their ultimate goals are to minimize the risk of cellular injuries to all types of patients undergoing cardiovascular therapies, treatments, or surgeries.

Original languageEnglish (US)
Title of host publicationHandbook of Cardiac Anatomy, Physiology, and Devices, Third Edition
PublisherSpringer International Publishing
Number of pages15
ISBN (Electronic)9783319194646
ISBN (Print)9783319194639
StatePublished - Jan 1 2015


  • Cardioprotection
  • Hibernating myocardium
  • Ischemic preconditioning
  • Maimed myocardium
  • Myocardial ischemia
  • Myocardial stunning
  • Reperfusion injury
  • Silent ischemia


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