Reverse mismatch between perfusion and aerosol ventilation in transplanted lungs

C. C. Kuni, Rene P Du Cret, R. E. Nakhleh, R. J. Boudreau

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Thirty ventilation-perfusion pulmonary scintigraphic studies were performed in 13 patients who had undergone unilateral lung transplantation. Ventilation-perfusion mismatch (ventilation better than perfusion) was judged absent, mild, moderate, or severe in the transplanted and native lungs. Ventilation-perfusion mismatch was significantly worse in the transplanted lungs (p<.0001). Findings of lung biopsies and chest roentgenograms failed to correlate with the severity of ventilation-perfusion mismatch. Hypoxic pulmonary vasoconstriction appears to be significantly impaired in most unilateral lung transplants; the mechanism for this impairment is unclear.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalClinical nuclear medicine
Issue number4
StatePublished - 1993


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