Reversal of myelofibrosis and splenomegaly is described in a 41 year old woman with metastatic breast cancer. After intensive chemotherapy and hormonal therapy, the tumor regressed, the splenomegaly receded, the hemogram showed no abnormalities, and the dense collagen and reticulin fibers in the marrow disappeared. The severe thrombocytopenia and leukoerythroblastosis noted before therapy were not obstacles to clinical management. In our report we document that myelofibrosis associated with breast cancer is not an ominous sign. Patients may benefit from an intensive, but well titrated, therapeutic program.
Bibliographical noteFunding Information:
From the Section of Medical Oncology, Departments of Medicine and of laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota. This research was supported by research grants CA-08101, CA-05158, CA-08832 and CB-64000 from the National Cancer Institute of the U.S. Public Health Service, the Minnesota Medical Foundation and the Masonic Memorial Hospital Fund, Inc. Requests for reprints should be addressed to Dr. David T. Kiang, Box 168. University Hospitals, Minneapolis, Minnesota 55455. Manuscript accepted September 20, 1976.