Abstract
Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor β, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor β.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2371-2373 |
| Number of pages | 3 |
| Journal | Infection and immunity |
| Volume | 63 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1995 |