Reversal of lipopolysaccharide-analog-induced antibody suppression by anti-transforming growth factor β and indomethacin

M. J. Odean, A. G. Johnson, M. Mohrman, A. Hasegawa

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor β, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor β.

Original languageEnglish (US)
Pages (from-to)2371-2373
Number of pages3
JournalInfection and immunity
Volume63
Issue number6
DOIs
StatePublished - 1995

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