Reversal by glucocorticoid hormones of the loss of a fibronectin and procollagen matrix around transformed human cells

Leo T Furcht, Gwen Wendelschafer-Crabb, Deane F. Mosher, Jean Michel Foidart

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Confluent cultured human skin fibroblasts had an extracellular fibrillar matrix of fibronectin and procollagen. Human skin fibroblasts transformed by SV40 did not have such a matrix. Treatment of transformed fibroblasts with 10-5 to 10-8 M dexamethasone and 10-5 to 10-7 M cortisol, but not testosterone or progesterone, caused partial restoration of the matrix. Glucocorticoid-treated transformed human fibroblasts can serve as a model for partial reversion toward normal or differentiation of transformed human fibroblasts.

Original languageEnglish (US)
Pages (from-to)2077-2083
Number of pages7
JournalCancer Research
Volume39
StatePublished - Jun 1 1979

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