Abstract
Confluent cultured human skin fibroblasts had an extracellular fibrillar matrix of fibronectin and procollagen. Human skin fibroblasts transformed by SV40 did not have such a matrix. Treatment of transformed fibroblasts with 10-5 to 10-8 M dexamethasone and 10-5 to 10-7 M cortisol, but not testosterone or progesterone, caused partial restoration of the matrix. Glucocorticoid-treated transformed human fibroblasts can serve as a model for partial reversion toward normal or differentiation of transformed human fibroblasts.
Original language | English (US) |
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Pages (from-to) | 2077-2083 |
Number of pages | 7 |
Journal | Cancer Research |
Volume | 39 |
State | Published - Jun 1 1979 |