Revenge of the "sit" II: Does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity?

Michelle W. Voss, Lucas J. Carr, Rachel Clark, Timothy Weng

Research output: Contribution to journalReview articlepeer-review

113 Scopus citations

Abstract

It is generally understood that regular moderate to vigorous physical activity (MVPA) promotes good health from head to toe. Evidence also supports the notion that too much sitting can increase all-cause mortality and risk of chronic diseases such as diabetes. Moreover, there is evidence that daily MVPA may not offset negative effects of sedentary behavior on systemic risk factors. We extend the discussion to brain structure and function and argue that while MVPA is recognized as a protective behavior against age-related dementia, sedentary behavior may also be an important contributor to brain health and even counteract the benefits of MVPA due to overlapping or interacting mechanistic pathways. Thus, the goals of this review are (1) to outline evidence linking both PA and sedentary behavior to neurobiological systems that are known to influence behavioral outcomes such as cognitive aging and (2) to propose productive areas of future research.

Original languageEnglish (US)
Pages (from-to)9-24
Number of pages16
JournalMental Health and Physical Activity
Volume7
Issue number1
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • Aging
  • Brain
  • Cognition
  • Exercise
  • Metabolic reserve
  • Sitting

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