Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi

Anne E.P. Frosch, Miriam K. Laufer, Don P. Mathanga, Shannon Takala-Harrison, Jacek Skarbinski, Cassidy W. Claassen, Fraction K. Dzinjalamala, Christopher V. Plowe

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41 Scopus citations

Abstract

Background: The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies. Methods: To characterize chloroquine susceptibility over a wide geographic area, infants and children aged 6-59 months were selected using 2-stage cluster sampling in 8 Malawian districts. Pyrosequencing of the pfcrt gene codon 76 region was performed for children with asexual parasitemia. Results: Of 7145 children, 1150 had microscopic asexual parasitemia, and sequencing was performed in 685, of whom 1 had a chloroquine-resistant genotype. Conclusions: Systematic countrywide sampling demonstrates that the chloroquine pfcrt genotype has reached near-fixation, raising the possibility of reintroducing chloroquine for malaria prevention and treatment.

Original languageEnglish (US)
Pages (from-to)1110-1114
Number of pages5
JournalJournal of Infectious Diseases
Volume210
Issue number7
DOIs
StatePublished - Oct 1 2014

Keywords

  • Africa
  • Chloroquine
  • Malaria
  • Malawi
  • PfCRT
  • Plasmodium falciparum
  • Resistance

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