In this chapter, we present an outline of retroviruses and retroviral vectors - the concepts and applications. In particular, we discuss lentiviral vectors and the suitability of these vectors for the treatment of renal pathologies. We review vector design and the data on the use of lentiviral vectors for gene transfer to the kidney. Finally, we discuss potential pathologies and avenues for the optimization of the technology for gene transfer to a complex organ such as the kidney.
|Original language||English (US)|
|Title of host publication||Gene Therapy for Renal Diseases and Transplantation|
|Editors||Ariela Benigni, Remuzzi Giuseppe|
|Number of pages||17|
|State||Published - 2008|
|Name||Contributions to Nephrology|
Copyright 2008 Elsevier B.V., All rights reserved.