Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1

Alper Yilmaz, Cheryl Bolinger, Kathleen Boris-Lawrie

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Human immunodeficiency virus type 1 (HIV-1) has a small, multifunctional genome that encodes a relatively large and complex proteome. The virus has adopted specialized post-transcriptional control mechanisms to maximize its coding capacity while economically maintaining the information stored in cis-acting replication sequences. The conserved features of the 5′ untranslated region of all viral transcripts suggest they are poor substrates for cap-dependent ribosome scanning and provide a compelling rationale for internal initiation of translation. This article summarizes key experimental results of studies that have evaluated HIV-1 translation initiation. A model is discussed in which cap-dependent and cap-independent initiation mechanisms of HIV-1 co-exist to ensure viral protein production in the context of 1) structured replication motifs that inhibit ribosome scanning, and 2) alterations in host translation machinery in response to HIV-1 infection or other cellular stresses. We discuss key issues that remain to be understood and suggest parameters to validate internal initiation activity in HIV-1 and other retroviruses.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalCurrent HIV research
Volume4
Issue number2
DOIs
StatePublished - Apr 2006

Keywords

  • 5′ untranslated region
  • Internal ribosome entry site
  • Retrovirus translational control
  • Ribosome scanning
  • Unspliced RNA

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