Retrovirus restriction factors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the major advances in the last decade of retrovirus research has been the discovery of cellular proteins that function to block viral replication. Retrovirus restriction factors such as APOBEC3G, TRIM5α and BST2 are dominant, variable, and interferon-inducible, and they have forced susceptible viruses to evolve intricate escape measures. This chapter will focus on these prototypical restriction factors and highlight several common themes.

Original languageEnglish (US)
Title of host publicationRecent Advances in Human Retroviruses
Subtitle of host publicationPrinciples of Replication and Pathogenesis: Advances in Retroviral Research
PublisherWorld Scientific Publishing Co.
Pages407-437
Number of pages31
ISBN (Electronic)9789814295314
ISBN (Print)9814295302, 9789814295307
DOIs
StatePublished - Jan 1 2010

Bibliographical note

Funding Information:
We thank Jeremy Luban, David Sayah, and Greg Towers for critically reading the manuscript. This review was written with the support of a grant from the National Institutes of Health (R01 CA 30488). S.P.G. is an Investigator of the Howard Hughes Medical Institute.

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