One of the major advances in the last decade of retrovirus research has been the discovery of cellular proteins that function to block viral replication. Retrovirus restriction factors such as APOBEC3G, TRIM5α and BST2 are dominant, variable, and interferon-inducible, and they have forced susceptible viruses to evolve intricate escape measures. This chapter will focus on these prototypical restriction factors and highlight several common themes.
|Original language||English (US)|
|Title of host publication||Recent Advances in Human Retroviruses|
|Subtitle of host publication||Principles of Replication and Pathogenesis: Advances in Retroviral Research|
|Publisher||World Scientific Publishing Co.|
|Number of pages||31|
|ISBN (Print)||9814295302, 9789814295307|
|State||Published - Jan 1 2010|
Bibliographical noteFunding Information:
We thank Jeremy Luban, David Sayah, and Greg Towers for critically reading the manuscript. This review was written with the support of a grant from the National Institutes of Health (R01 CA 30488). S.P.G. is an Investigator of the Howard Hughes Medical Institute.