Retroviral vector targeting to human immunodeficiency virus type 1- infected cells by receptor pseudotyping

Nikunj V. Somia, Hiroyuki Miyoshi, Mark J. Schmitt, Inder M. Verma

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We report the generation of retroviral vectors based on Moloney murine leukemia virus that specifically transduce cells infected with T-cell-tropic human immunodeficiency virus type 1 (HIV-1). This vector was pseudotyped with T-cell-tropic HIV-1 receptors CD4 and CXCR4. We demonstrate that transduction is contingent upon HIV-1 gp120 and gp41 expression.

Original languageEnglish (US)
Pages (from-to)4420-4424
Number of pages5
JournalJournal of virology
Volume74
Issue number9
DOIs
StatePublished - 2000

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