Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): A comparison of their molecular and biochemical properties

Amnon Hizi, Alon Herschhorn

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

This chapter reviews most of the biochemical data on reverse transcriptases (RTs) of retroviruses, other than those of HIV-1 and murine leukemia virus (MLV) that are covered in detail in other reviews of this special edition devoted to reverse transcriptases. The various RTs mentioned are grouped according to their retroviral origins and include the RTs of the alpharetroviruses, lentiviruses (both primate, other than HIV-1, and non-primate lentiviruses), betaretroviruses, deltaretroviruses and spumaretroviruses. For each RT group, the processing, molecular organization as well as the enzymatic activities and biochemical properties are described. Several RTs function as dimers, primarily as heterodimers, while the others are active as monomeric proteins. The comparisons between the diverse properties of the various RTs show the common traits that characterize the RTs from all retroviral subfamilies. In addition, the unique features of the specific RTs groups are also discussed.

Original languageEnglish (US)
Pages (from-to)203-220
Number of pages18
JournalVirus Research
Volume134
Issue number1-2
DOIs
StatePublished - Jun 1 2008

Keywords

  • Alpharetroviruses
  • Betaretroviruses
  • Deltaretroviruses
  • Primate and non-primate lentiviruses
  • RT groups
  • Spumaretroviruses

Fingerprint Dive into the research topics of 'Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): A comparison of their molecular and biochemical properties'. Together they form a unique fingerprint.

  • Cite this