Retroviral insertional mutagenesis in mouse models of leukemia and lymphoma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Leukemia and lymphoma are cancers derived from cellular elements of the hematopoietic system. While they make up a minority of human cancer morbidity and mortality, the study of these cancers has illuminated many important aspects of cancer development and biology. In fact, the leukemias and lymphomas are among the best-studied and well understood types of cancer from a genetic perspective. In part, this may derive from the fact that these types of cancer are highly amenable to study using models in which mice are chronically infected with a retrovirus so as to induce or accelerate the disease. In this chapter, I have briefly reviewed the long and rich history of cancer studies using the murine leukemia viruses (MLV). Special attention has been paid to the replication competent MLV that typically cause cancer after a long latency and via insertional mutagenesis. This is followed by a discussion of the limitations of these models and suggestions for future work.

Original languageEnglish (US)
Title of host publicationInsertional Mutagenesis Strategies in Cancer Genetics
PublisherSpringer New York
Pages19-38
Number of pages20
ISBN (Print)9781441976550
DOIs
StatePublished - 2011

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