TY - CHAP
T1 - Retroviral insertional mutagenesis in mouse models of leukemia and lymphoma
AU - Largaespada, David A.
PY - 2011
Y1 - 2011
N2 - Leukemia and lymphoma are cancers derived from cellular elements of the hematopoietic system. While they make up a minority of human cancer morbidity and mortality, the study of these cancers has illuminated many important aspects of cancer development and biology. In fact, the leukemias and lymphomas are among the best-studied and well understood types of cancer from a genetic perspective. In part, this may derive from the fact that these types of cancer are highly amenable to study using models in which mice are chronically infected with a retrovirus so as to induce or accelerate the disease. In this chapter, I have briefly reviewed the long and rich history of cancer studies using the murine leukemia viruses (MLV). Special attention has been paid to the replication competent MLV that typically cause cancer after a long latency and via insertional mutagenesis. This is followed by a discussion of the limitations of these models and suggestions for future work.
AB - Leukemia and lymphoma are cancers derived from cellular elements of the hematopoietic system. While they make up a minority of human cancer morbidity and mortality, the study of these cancers has illuminated many important aspects of cancer development and biology. In fact, the leukemias and lymphomas are among the best-studied and well understood types of cancer from a genetic perspective. In part, this may derive from the fact that these types of cancer are highly amenable to study using models in which mice are chronically infected with a retrovirus so as to induce or accelerate the disease. In this chapter, I have briefly reviewed the long and rich history of cancer studies using the murine leukemia viruses (MLV). Special attention has been paid to the replication competent MLV that typically cause cancer after a long latency and via insertional mutagenesis. This is followed by a discussion of the limitations of these models and suggestions for future work.
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U2 - 10.1007/978-1-4419-7656-7_2
DO - 10.1007/978-1-4419-7656-7_2
M3 - Chapter
AN - SCOPUS:84900669098
SN - 9781441976550
SP - 19
EP - 38
BT - Insertional Mutagenesis Strategies in Cancer Genetics
PB - Springer New York
ER -