TY - JOUR
T1 - Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging
AU - Chen, Wei
AU - Zhu, Xiao Hong
AU - Thulborn, Keith R.
AU - Ugurbil, Kamil
PY - 1999/3/2
Y1 - 1999/3/2
N2 - Subcortical nuclei in the thalamus, which play an important role in many functions of the human brain, provide challenging targets for functional mapping with neuroimaging techniques because of their small sizes and deep locations. In this study, we explore the capability of high-resolution functional magnetic resonance imaging at 4 Tesla for mapping the retinotopic organization in the lateral geniculate nucleus (LGN). Our results show that the hemifield visual stimulation only activates LGN in the contralateral hemisphere, and the lower-field and upper-field visual stimulations activate the superior and inferior portion of LGN, respectively. These results reveal a similar retinotopic organization between the human and nonhuman primate LGN and between LGN and the primary visual cortex. We conclude that high- resolution functional magnetic resonance imaging is capable of functional mapping of suborganizations in small nuclei together with cortical activation. This will have an impact for studying tile thalamocortical networks in the human brain.
AB - Subcortical nuclei in the thalamus, which play an important role in many functions of the human brain, provide challenging targets for functional mapping with neuroimaging techniques because of their small sizes and deep locations. In this study, we explore the capability of high-resolution functional magnetic resonance imaging at 4 Tesla for mapping the retinotopic organization in the lateral geniculate nucleus (LGN). Our results show that the hemifield visual stimulation only activates LGN in the contralateral hemisphere, and the lower-field and upper-field visual stimulations activate the superior and inferior portion of LGN, respectively. These results reveal a similar retinotopic organization between the human and nonhuman primate LGN and between LGN and the primary visual cortex. We conclude that high- resolution functional magnetic resonance imaging is capable of functional mapping of suborganizations in small nuclei together with cortical activation. This will have an impact for studying tile thalamocortical networks in the human brain.
UR - http://www.scopus.com/inward/record.url?scp=0033515080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033515080&partnerID=8YFLogxK
U2 - 10.1073/pnas.96.5.2430
DO - 10.1073/pnas.96.5.2430
M3 - Article
C2 - 10051659
AN - SCOPUS:0033515080
VL - 96
SP - 2430
EP - 2434
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 5
ER -