Retinoic acid induction of mouse cellular retinoic acid-binding protein-I gene expression is enhanced by sphinganine

Li-Na Wei, Chih Hao Lee, Liming Chang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Cellular retinoic acid-binding protein-I (CRABP-I) gene expression is induced in mouse embryonal carcinoma P19 cells specifically by retinoic acid (RA) and the induction is enhanced by sphinganine. The effects of retinoic acid and sphinganine on CRABP-I gene expression can be accounted for by a stimulation of its transcription rate. Using a lacZ reporter system, it was determined that a DNA fragment containing a putative AP-1 binding site in the promoter region of CRABP-I gene is required for the up-regulation of CRABP-I gene transcription.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume111
Issue number2
DOIs
StatePublished - Jun 1995

Keywords

  • AP-1
  • Cellular retinoic acid-binding protein-I
  • Gene regulation
  • Sphinganine

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