Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors

Edward J. Wu; Dennis J. Goussetis; Elspeth Beauchamp; Ewa M. Kosciuczuk; Jessica K. Altman; Elizabeth A. Eklund; Leonidas C. Platanias

doi:10.4161/cbt.27824

Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors

Edward J. Wu, Dennis J. Goussetis, Elspeth Beauchamp, Ewa M. Kosciuczuk, Jessica K. Altman, Elizabeth A. Eklund, Leonidas C. Platanias

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Efforts to enhance the antileukemic properties of arsenic trioxide are clinically relevant and may lead to the development of new therapeutic approaches for the management of certain hematological malignancies. We provide evidence that concomitant treatment of acute myeloid leukemia (AML) cells or chronic myeloid leukemia (CML) cells with resveratrol potentiates arsenic trioxide-dependent induction of apoptosis. Importantly, clonogenic assays in methylcellulose demonstrate potent suppressive effects of the combination of these agents on primitive leukemic progenitors derived from patients with AML or CML. Taken together, these findings suggest that combinations of arsenic trioxide with resveratrol may provide an approach for targeting of early leukemic precursors and, possibly, leukemia initiating stem cells.

Original language	English (US)
Pages (from-to)	473-478
Number of pages	6
Journal	Cancer Biology and Therapy
Volume	15
Issue number	4
DOIs	https://doi.org/10.4161/cbt.27824
State	Published - Apr 2014
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health grants CA121192, CA155566, CA77816, and CA174205; and by grant I01CX000916 from the Department of Veterans Affairs. E.B. was supported by NIH training grant T32CA070085.

Keywords

Apoptosis
Arsenic trioxide
Autophagy
Myeloid leukemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cbt.27824

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title = "Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors",

abstract = "Efforts to enhance the antileukemic properties of arsenic trioxide are clinically relevant and may lead to the development of new therapeutic approaches for the management of certain hematological malignancies. We provide evidence that concomitant treatment of acute myeloid leukemia (AML) cells or chronic myeloid leukemia (CML) cells with resveratrol potentiates arsenic trioxide-dependent induction of apoptosis. Importantly, clonogenic assays in methylcellulose demonstrate potent suppressive effects of the combination of these agents on primitive leukemic progenitors derived from patients with AML or CML. Taken together, these findings suggest that combinations of arsenic trioxide with resveratrol may provide an approach for targeting of early leukemic precursors and, possibly, leukemia initiating stem cells.",

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note = "Funding Information: This work was supported by National Institutes of Health grants CA121192, CA155566, CA77816, and CA174205; and by grant I01CX000916 from the Department of Veterans Affairs. E.B. was supported by NIH training grant T32CA070085.",

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language = "English (US)",

volume = "15",

pages = "473--478",

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AU - Wu, Edward J.

AU - Goussetis, Dennis J.

AU - Beauchamp, Elspeth

AU - Kosciuczuk, Ewa M.

AU - Altman, Jessica K.

AU - Eklund, Elizabeth A.

AU - Platanias, Leonidas C.

N1 - Funding Information: This work was supported by National Institutes of Health grants CA121192, CA155566, CA77816, and CA174205; and by grant I01CX000916 from the Department of Veterans Affairs. E.B. was supported by NIH training grant T32CA070085.

PY - 2014/4

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N2 - Efforts to enhance the antileukemic properties of arsenic trioxide are clinically relevant and may lead to the development of new therapeutic approaches for the management of certain hematological malignancies. We provide evidence that concomitant treatment of acute myeloid leukemia (AML) cells or chronic myeloid leukemia (CML) cells with resveratrol potentiates arsenic trioxide-dependent induction of apoptosis. Importantly, clonogenic assays in methylcellulose demonstrate potent suppressive effects of the combination of these agents on primitive leukemic progenitors derived from patients with AML or CML. Taken together, these findings suggest that combinations of arsenic trioxide with resveratrol may provide an approach for targeting of early leukemic precursors and, possibly, leukemia initiating stem cells.

AB - Efforts to enhance the antileukemic properties of arsenic trioxide are clinically relevant and may lead to the development of new therapeutic approaches for the management of certain hematological malignancies. We provide evidence that concomitant treatment of acute myeloid leukemia (AML) cells or chronic myeloid leukemia (CML) cells with resveratrol potentiates arsenic trioxide-dependent induction of apoptosis. Importantly, clonogenic assays in methylcellulose demonstrate potent suppressive effects of the combination of these agents on primitive leukemic progenitors derived from patients with AML or CML. Taken together, these findings suggest that combinations of arsenic trioxide with resveratrol may provide an approach for targeting of early leukemic precursors and, possibly, leukemia initiating stem cells.

KW - Apoptosis

KW - Arsenic trioxide

KW - Autophagy

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Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors

Abstract

Bibliographical note

Keywords

UN SDGs

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