TY - JOUR
T1 - Resveratrol and beyond
T2 - The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review
AU - Gál, Roland
AU - Halmosi, Róbert
AU - Gallyas, Ferenc
AU - Tschida, Michael
AU - Mutirangura, Pornthira
AU - Tóth, Kálmán
AU - Alexy, Tamás
AU - Czopf, László
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/11
Y1 - 2023/11
N2 - Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Unhealthy dietary habits have clearly been shown to contribute to the development of CVDs. Beyond the primary nutrients, a healthy diet is also rich in plant-derived compounds. Natural polyphenols, found in fruits, vegetables, and red wine, have a clear role in improving cardiovascular health. In this review, we strive to summarize the results of the relevant pre-clinical and clinical trials that focused on some of the most important natural polyphenols, such as resveratrol and relevant flavonoids. In addition, we aim to identify their common sources, biosynthesis, and describe their mechanism of action including their regulatory effect on signal transduction pathways. Finally, we provide scientific evidence regarding the cardiovascular benefits of moderate, long-term red wine consumption.
AB - Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Unhealthy dietary habits have clearly been shown to contribute to the development of CVDs. Beyond the primary nutrients, a healthy diet is also rich in plant-derived compounds. Natural polyphenols, found in fruits, vegetables, and red wine, have a clear role in improving cardiovascular health. In this review, we strive to summarize the results of the relevant pre-clinical and clinical trials that focused on some of the most important natural polyphenols, such as resveratrol and relevant flavonoids. In addition, we aim to identify their common sources, biosynthesis, and describe their mechanism of action including their regulatory effect on signal transduction pathways. Finally, we provide scientific evidence regarding the cardiovascular benefits of moderate, long-term red wine consumption.
KW - cardiovascular diseases
KW - inflammation
KW - oxidative stress
KW - polyphenols
KW - resveratrol
UR - http://www.scopus.com/inward/record.url?scp=85178337117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178337117&partnerID=8YFLogxK
U2 - 10.3390/biomedicines11112888
DO - 10.3390/biomedicines11112888
M3 - Review article
C2 - 38001889
AN - SCOPUS:85178337117
SN - 2227-9059
VL - 11
JO - Biomedicines
JF - Biomedicines
IS - 11
M1 - 2888
ER -
