TY - JOUR
T1 - Results of Repeat Sigmoidoscopy 3 Years after a Negative Examination
AU - Schoen, Robert E.
AU - Pinsky, Paul F.
AU - Weissfeld, Joel L.
AU - Bresalier, Robert S.
AU - Church, Timothy
AU - Prorok, Philip
AU - Gohagan, John K.
PY - 2003/7/2
Y1 - 2003/7/2
N2 - Context: The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain. Objective: To examine the yield of adenomas and cancer in the distal colon found by repeat flexible sigmoidoscopy (FSG) 3 years after a negative examination. Design, Setting, and Participants: Participants were drawn from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), a randomized, controlled community-based study of cancer screening. The mean (SD) age was 65.7 (4.0) years at study entry (1993-1995) and 61.6% were men. Individuals underwent screening FSG at baseline and at 3 years as part of the protocol and were referred to their personal physicians for further evaluation of screen-detected abnormalities. Results from subsequent diagnostic evaluations were tracked in a standardized fashion. Of 11583 eligible for repeat screening FSG 3 years after an initial negative examination, 9317 (80.4%) returned. Main Outcome Measures: Polyp or mass detection in distal colon at year 3 repeat FSG; incidence of adenoma or cancer in distal colon at year 3 examination; determination of reason for detection (increased depth of insertion or improved preparation at the year 3 examination or detection in a previously examined area). Results: A total of 1292 returning participants (13.9%) had a polyp or mass detected by FSG 3 years after the initial examination. In the distal colon, 3.1% (292/ 9317) were found to have an adenoma or cancer. The incidence of advanced adenoma (n = 72) or cancer (n=6) in the distal colon was 78 (0.8%) of 9317. Of individuals with advanced distal adenomas detected at the year 3 examination, 80.6% (58/72) had lesions found in a portion of the colon that had been adequately examined at the initial sigmoidoscopy. Conclusions: Repeat FSG 3 years after a negative examination will detect advanced adenomas and distal colon cancer. Although the overall percentage with detected abnormalities is modest, these data raise concern about the impact of a prolonged screening interval after a negative examination.
AB - Context: The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain. Objective: To examine the yield of adenomas and cancer in the distal colon found by repeat flexible sigmoidoscopy (FSG) 3 years after a negative examination. Design, Setting, and Participants: Participants were drawn from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), a randomized, controlled community-based study of cancer screening. The mean (SD) age was 65.7 (4.0) years at study entry (1993-1995) and 61.6% were men. Individuals underwent screening FSG at baseline and at 3 years as part of the protocol and were referred to their personal physicians for further evaluation of screen-detected abnormalities. Results from subsequent diagnostic evaluations were tracked in a standardized fashion. Of 11583 eligible for repeat screening FSG 3 years after an initial negative examination, 9317 (80.4%) returned. Main Outcome Measures: Polyp or mass detection in distal colon at year 3 repeat FSG; incidence of adenoma or cancer in distal colon at year 3 examination; determination of reason for detection (increased depth of insertion or improved preparation at the year 3 examination or detection in a previously examined area). Results: A total of 1292 returning participants (13.9%) had a polyp or mass detected by FSG 3 years after the initial examination. In the distal colon, 3.1% (292/ 9317) were found to have an adenoma or cancer. The incidence of advanced adenoma (n = 72) or cancer (n=6) in the distal colon was 78 (0.8%) of 9317. Of individuals with advanced distal adenomas detected at the year 3 examination, 80.6% (58/72) had lesions found in a portion of the colon that had been adequately examined at the initial sigmoidoscopy. Conclusions: Repeat FSG 3 years after a negative examination will detect advanced adenomas and distal colon cancer. Although the overall percentage with detected abnormalities is modest, these data raise concern about the impact of a prolonged screening interval after a negative examination.
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M3 - Article
C2 - 12837710
AN - SCOPUS:0037490173
SN - 0098-7484
VL - 290
SP - 41
EP - 48
JO - JAMA
JF - JAMA
IS - 1
ER -
