Restless legs syndrome associated with use of stevia nonnutritive sweetener

Research output: Contribution to journalArticlepeer-review


Restless legs syndrome is a common sensorimotor movement disorder affecting an estimated 15–20% of the general adult population in the United Sates. Several drugs and drug classes have been shown to either cause and/or exacerbate symptoms of restless legs syndrome. With the epidemic of obesity and the heightened awareness of the harmful effects of added sugars, the consumption of low and no-calorie sweeteners has substantially increased. We report a case where the patient developed restless legs syndrome symptoms with the use of a stevia extract–based no calorie sweetener. To our knowledge, this is the first case report of restless legs syndrome possibly associated with low or no-calorie sweetener use.

Original languageEnglish (US)
Pages (from-to)1819-1821
Number of pages3
JournalJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Issue number10
Early online dateJul 21 2020
StatePublished - Oct 15 2020

Bibliographical note

Publisher Copyright:
Copyright 2020 American Academy of Sleep Medicine. All rights reserved.


  • dopamine
  • obesity
  • restless legs syndrome
  • RLS
  • stevia
  • Restless legs syndrome
  • Dopamine
  • Stevia; obesity

PubMed: MeSH publication types

  • Case Reports


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