Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting-state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- to habit- oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p <.01). Exploratory correlations between RSFC z-scores and Eating Disorder Examination (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated lower RSFC between the NAcc and superior frontal gyrus, between the ventral caudate and frontal and posterior regions, and between the dorsal caudate and frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior frontal gyrus RSFC correlated with greater EDE Global scores (r = −.58, CI: −.83, −.13). These resting-state synchrony disruptions of the ventral and dorsal frontostriatal circuits, considered in context of the broader literature, support the utility of further investigating possible reward and habit disturbances supporting symptoms in AN.

Original languageEnglish (US)
Pages (from-to)652-662
Number of pages11
JournalHuman Brain Mapping
Volume40
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Anorexia Nervosa
Reward
Habits
Nucleus Accumbens
Prefrontal Cortex
Temporal Lobe
Cues
Seeds
Healthy Volunteers
Learning
Food
Brain
Research

Keywords

  • anorexia nervosa
  • eating disorder
  • functional connectivity
  • habit
  • resting state fMRI
  • reward

PubMed: MeSH publication types

  • Journal Article

Cite this

@article{84f2e8d8e910496c8d79930c984570e8,
title = "Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa",
abstract = "Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting-state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- to habit- oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p <.01). Exploratory correlations between RSFC z-scores and Eating Disorder Examination (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated lower RSFC between the NAcc and superior frontal gyrus, between the ventral caudate and frontal and posterior regions, and between the dorsal caudate and frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior frontal gyrus RSFC correlated with greater EDE Global scores (r = −.58, CI: −.83, −.13). These resting-state synchrony disruptions of the ventral and dorsal frontostriatal circuits, considered in context of the broader literature, support the utility of further investigating possible reward and habit disturbances supporting symptoms in AN.",
keywords = "anorexia nervosa, eating disorder, functional connectivity, habit, resting state fMRI, reward",
author = "Haynos, {Ann F} and Hall, {Leah M.J.} and Lavender, {Jason M.} and Peterson, {Carol B} and Crow, {Scott J} and Bonnie Klimes-Dougan and Cullen, {Kathryn R} and Lim, {Kelvin O} and Jazmin Camchong",
year = "2019",
month = "2",
day = "1",
doi = "10.1002/hbm.24402",
language = "English (US)",
volume = "40",
pages = "652--662",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa

AU - Haynos, Ann F

AU - Hall, Leah M.J.

AU - Lavender, Jason M.

AU - Peterson, Carol B

AU - Crow, Scott J

AU - Klimes-Dougan, Bonnie

AU - Cullen, Kathryn R

AU - Lim, Kelvin O

AU - Camchong, Jazmin

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting-state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- to habit- oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p <.01). Exploratory correlations between RSFC z-scores and Eating Disorder Examination (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated lower RSFC between the NAcc and superior frontal gyrus, between the ventral caudate and frontal and posterior regions, and between the dorsal caudate and frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior frontal gyrus RSFC correlated with greater EDE Global scores (r = −.58, CI: −.83, −.13). These resting-state synchrony disruptions of the ventral and dorsal frontostriatal circuits, considered in context of the broader literature, support the utility of further investigating possible reward and habit disturbances supporting symptoms in AN.

AB - Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting-state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- to habit- oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p <.01). Exploratory correlations between RSFC z-scores and Eating Disorder Examination (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated lower RSFC between the NAcc and superior frontal gyrus, between the ventral caudate and frontal and posterior regions, and between the dorsal caudate and frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior frontal gyrus RSFC correlated with greater EDE Global scores (r = −.58, CI: −.83, −.13). These resting-state synchrony disruptions of the ventral and dorsal frontostriatal circuits, considered in context of the broader literature, support the utility of further investigating possible reward and habit disturbances supporting symptoms in AN.

KW - anorexia nervosa

KW - eating disorder

KW - functional connectivity

KW - habit

KW - resting state fMRI

KW - reward

UR - http://www.scopus.com/inward/record.url?scp=85053799415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053799415&partnerID=8YFLogxK

U2 - 10.1002/hbm.24402

DO - 10.1002/hbm.24402

M3 - Article

C2 - 30251758

AN - SCOPUS:85053799415

VL - 40

SP - 652

EP - 662

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 2

ER -