Resting-state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain

Shinho Cho, Jan T. Hachmann, Irena Balzekas, Myung Ho In, Lindsey G. Andres-Beck, Kendall H. Lee, Hoon Ki Min, Hang Joon Jo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Introduction: While the clinical efficacy of deep brain stimulation (DBS) the treatment of motor-related symptoms is well established, the mechanism of action of the resulting cognitive and behavioral effects has been elusive. Methods: By combining functional magnetic resonance imaging (fMRI) and DBS, we investigated the pattern of blood-oxygenation-level-dependent (BOLD) signal changes induced by stimulating the nucleus accumbens in a large animal model. Results: We found that diffused BOLD activation across multiple functional networks, including the prefrontal, limbic, and thalamic regions during the stimulation, resulted in a significant change in inter-regional functional connectivity. More importantly, the magnitude of the modulation was closely related to the strength of the inter-regional resting-state functional connectivity. Conclusions: Nucleus accumbens stimulation affects the functional activity in networks that underlie cognition and behavior. Our study provides an insight into the nature of the functional connectivity, which mediates activation effect via brain networks.

Original languageEnglish (US)
Article numbere01431
JournalBrain and Behavior
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2019

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (NIH C06 RR018898 and NIH R01 NS70872), Hanyang University (HY‐2019), and the Grainger Foundation.

Keywords

  • blood-oxygenation-level-dependent hemodynamic response
  • deep brain stimulation
  • functional connectivity change
  • functional magnetic resonance imaging
  • network effect
  • nucleus accumbens
  • resting-state functional connectivity

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