Responses to light of retinal neurons regenerating axons into peripheral nerve grafts in the rat

Susan A. Keirstead; Manuel Vidal-Sanz; Michael Rasminsky; Albert J. Aguayo; Michel Levesque; Kwok Fai So

doi:10.1016/0006-8993(85)91461-1

Responses to light of retinal neurons regenerating axons into peripheral nerve grafts in the rat

Susan A. Keirstead
, Manuel Vidal-Sanz
, Michael Rasminsky
, Albert J. Aguayo
, Michel Levesque
, Kwok Fai So

Integrative Biology and Physiology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We have recorded unitary activity from axons regenerated into peripheral nerve grafts inserted into the retina of adult rats. Some retinal ganglion cells regenerating axons into these grafts had responses to light similar to those of intact retinal ganglion cells. The number of units that responded to light in these blind-ended grafts declined between 9 and 48 weeks after graft insertion. Axotomized retinal ganglion cells regenerating axons into peripheral nerve grafts thus appear, at least temporarily, to maintain or resume normal function.

Original language	English (US)
Pages (from-to)	402-406
Number of pages	5
Journal	Brain Research
Volume	359
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)91461-1
State	Published - Dec 16 1985

Bibliographical note

Funding Information:
This investigatiowna s supportedb y the Medical ResearchC ouncila ndthe Multiple SclerosisS ociety of Canada.M .V.S. was supportedb y a grant from the SpanishM inistryo f Educationa nd Science.W e thankD r. Ursula Dr~igerfo r helpful advice.S killful technicala ssistancew as providedb y Janet Laga-ni6re.

Keywords

axonal elongation
axotomy
central nervous system regeneration
electrophysiology
nerve transplant
rat
receptive field
retina
vision

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10.1016/0006-8993(85)91461-1

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title = "Responses to light of retinal neurons regenerating axons into peripheral nerve grafts in the rat",

abstract = "We have recorded unitary activity from axons regenerated into peripheral nerve grafts inserted into the retina of adult rats. Some retinal ganglion cells regenerating axons into these grafts had responses to light similar to those of intact retinal ganglion cells. The number of units that responded to light in these blind-ended grafts declined between 9 and 48 weeks after graft insertion. Axotomized retinal ganglion cells regenerating axons into peripheral nerve grafts thus appear, at least temporarily, to maintain or resume normal function.",

keywords = "axonal elongation, axotomy, central nervous system regeneration, electrophysiology, nerve transplant, rat, receptive field, retina, vision",

author = "Keirstead, \{Susan A.\} and Manuel Vidal-Sanz and Michael Rasminsky and Aguayo, \{Albert J.\} and Michel Levesque and So, \{Kwok Fai\}",

note = "Funding Information: This investigatiowna s supportedb y the Medical ResearchC ouncila ndthe Multiple SclerosisS ociety of Canada.M .V.S. was supportedb y a grant from the SpanishM inistryo f Educationa nd Science.W e thankD r. Ursula Dr\textasciitilde{}igerfo r helpful advice.S killful technicala ssistancew as providedb y Janet Laga-ni6re.",

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doi = "10.1016/0006-8993(85)91461-1",

language = "English (US)",

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pages = "402--406",

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T1 - Responses to light of retinal neurons regenerating axons into peripheral nerve grafts in the rat

AU - Keirstead, Susan A.

AU - Vidal-Sanz, Manuel

AU - Rasminsky, Michael

AU - Aguayo, Albert J.

AU - Levesque, Michel

AU - So, Kwok Fai

N1 - Funding Information: This investigatiowna s supportedb y the Medical ResearchC ouncila ndthe Multiple SclerosisS ociety of Canada.M .V.S. was supportedb y a grant from the SpanishM inistryo f Educationa nd Science.W e thankD r. Ursula Dr~igerfo r helpful advice.S killful technicala ssistancew as providedb y Janet Laga-ni6re.

PY - 1985/12/16

Y1 - 1985/12/16

N2 - We have recorded unitary activity from axons regenerated into peripheral nerve grafts inserted into the retina of adult rats. Some retinal ganglion cells regenerating axons into these grafts had responses to light similar to those of intact retinal ganglion cells. The number of units that responded to light in these blind-ended grafts declined between 9 and 48 weeks after graft insertion. Axotomized retinal ganglion cells regenerating axons into peripheral nerve grafts thus appear, at least temporarily, to maintain or resume normal function.

AB - We have recorded unitary activity from axons regenerated into peripheral nerve grafts inserted into the retina of adult rats. Some retinal ganglion cells regenerating axons into these grafts had responses to light similar to those of intact retinal ganglion cells. The number of units that responded to light in these blind-ended grafts declined between 9 and 48 weeks after graft insertion. Axotomized retinal ganglion cells regenerating axons into peripheral nerve grafts thus appear, at least temporarily, to maintain or resume normal function.

KW - axonal elongation

KW - axotomy

KW - central nervous system regeneration

KW - electrophysiology

KW - nerve transplant

KW - rat

KW - receptive field

KW - retina

KW - vision

UR - https://www.scopus.com/pages/publications/0022372789

UR - https://www.scopus.com/pages/publications/0022372789#tab=citedBy

U2 - 10.1016/0006-8993(85)91461-1

DO - 10.1016/0006-8993(85)91461-1

M3 - Article

C2 - 4075162

AN - SCOPUS:0022372789

SN - 0006-8993

VL - 359

SP - 402

EP - 406

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Responses to light of retinal neurons regenerating axons into peripheral nerve grafts in the rat

Abstract

Bibliographical note

Keywords

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