Responses to light of retinal neurons regenerating axons into peripheral nerve grafts in the rat

Susan A. Keirstead, Manuel Vidal-Sanz, Michael Rasminsky, Albert J. Aguayo, Michel Levesque, Kwok Fai So

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

We have recorded unitary activity from axons regenerated into peripheral nerve grafts inserted into the retina of adult rats. Some retinal ganglion cells regenerating axons into these grafts had responses to light similar to those of intact retinal ganglion cells. The number of units that responded to light in these blind-ended grafts declined between 9 and 48 weeks after graft insertion. Axotomized retinal ganglion cells regenerating axons into peripheral nerve grafts thus appear, at least temporarily, to maintain or resume normal function.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalBrain Research
Volume359
Issue number1-2
DOIs
StatePublished - Dec 16 1985

Keywords

  • axonal elongation
  • axotomy
  • central nervous system regeneration
  • electrophysiology
  • nerve transplant
  • rat
  • receptive field
  • retina
  • vision

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