Individuals with schizophrenia exhibit widespread cortical thinning associated with illness severity and deficits in cognition. However, intact cortical thickness (CTh) may serve as a protective factor. The current study sought to examine changes in CTh in response to auditory targeted cognitive training (TCT) in individuals with recent onset schizophrenia. Participants underwent MRI scanning and a cognitive assessment before and after being randomly assigned to 40 h of either TCT (N = 21) or a computer games control condition (CG; N = 22) over 16 weeks. Groups did not differ at baseline on demographic variables or measures of CTh. At the level of group averages, neither group showed significant pre-post changes in CTh in any brain region. However, changes in CTh related to individual differences in treatment outcome, as improved global cognition in the TCT group corresponded to reduced cortical thinning in frontal, temporal, parietal, and occipital lobes. These relationships were not observed in the CG group. The current findings suggest that TCT may be neuroprotective in early schizophrenia, such that individuals who improved in response to training also showed a reduction in cortical thinning that may be otherwise hastened due to age and illness.
|Original language||English (US)|
|Journal||Psychiatry Research - Neuroimaging|
|State||Published - Jun 30 2021|
Bibliographical noteFunding Information:
Funding was provided by the Stanley Medical Research Institute (06TAF-972) and the National Institute of Mental Health (MH076989). ISR was funded by the Wells Family Trust and the National Institute of Mental Health (K01 MH117451). Posit Science Inc. supplied the training software used in this study free of charge.
The current study was funded by the Stanley Medical Research Institute (06TAF-972) and the National Institute of Mental Health (MH076989). ISR was funded by the Wells Family Trust and the National Institute of Mental Health (K01 MH117451).
© 2021 Elsevier B.V.
- Cognitive training
- Cortical thickness
- Early schizophrenia
- Structural MRI