Response to hepatitis B virus vaccination in individuals with chronic hepatitis C virus infection

Ashraf A. Ashhab; Holly Rodin; Marilia Campos; Ahmad Abu-Sulb; Jane A. Hall; Jesse Powell; Jose D. Debes

doi:10.1371/journal.pone.0237398

Response to hepatitis B virus vaccination in individuals with chronic hepatitis C virus infection

Ashraf A. Ashhab, Holly Rodin, Marilia Campos, Ahmad Abu-Sulb, Jane A. Hall, Jesse Powell, Jose D. Debes

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background Previous reports show conflicting results regarding hepatitis B virus (HBV) vaccine efficacy in Hepatitis C virus (HCV)-infected individuals. Aims To evaluate HBV-vaccine response and identify possible factors that may contribute to lower vaccine efficacy in patients infected with HCV. Methods We retrospectively evaluated all patients with chronic HCV infection at Hennepin County Medical Center, in Minneapolis, Minnesota, between 2002 and 2018. We addressed laboratory, liver-related, virus-related as well as vaccine-related variables, and their association to HBV vaccine response. Differences were tested using either a Chi-squared test or a T test to compare means between the two populations. Multivariate regression was modeled as a logistic regression. Results 1506 patients were evaluated, of which 525 received appropriate HBV vaccination and were assessed for response. Among those, 79% were vaccine responders and 21% were nonresponders. On multivariate analysis, cirrhosis was associated with lower response to the vaccine (OR 0.6, CI 0.44–0.94). We found no significant differences for vaccine response in relation to smoking (87% vs 86%), IV drug abuse (74% vs 72%), Diabetes Mellitus (26% vs 22%) being on hemodialysis (2% vs.5%), or virus related variables. Conclusion HCV infection seems to impair HBV vaccine response, with cirrhosis being the only identifiable risk factor for hypo-responsiveness among studied clinical and virus-related variables.

Original language	English (US)
Article number	e0237398
Journal	PloS one
Volume	15
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0237398
State	Published - Aug 2020

Bibliographical note

Funding Information:
JD is supported by the Robert Wood Johnson Foundation, Harold Amos Medical Faculty Development Program(AMFDP) and National Institute of Health (NIH) -NCI R21 CA215883-01A1. URLs: Robert Wood Johnson Foundation: www.rwjf.org Harold Amos Medical Faculty Development Program: www.amfdp.org/National institute of health: www.nih.gov The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
Copyright: © 2020 Ashhab et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

Female
Hepatitis B virus/immunology
Hepatitis C, Chronic/prevention & control
Humans
Life Style
Male
Middle Aged
Treatment Outcome
Vaccination

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0237398

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title = "Response to hepatitis B virus vaccination in individuals with chronic hepatitis C virus infection",

abstract = "Background Previous reports show conflicting results regarding hepatitis B virus (HBV) vaccine efficacy in Hepatitis C virus (HCV)-infected individuals. Aims To evaluate HBV-vaccine response and identify possible factors that may contribute to lower vaccine efficacy in patients infected with HCV. Methods We retrospectively evaluated all patients with chronic HCV infection at Hennepin County Medical Center, in Minneapolis, Minnesota, between 2002 and 2018. We addressed laboratory, liver-related, virus-related as well as vaccine-related variables, and their association to HBV vaccine response. Differences were tested using either a Chi-squared test or a T test to compare means between the two populations. Multivariate regression was modeled as a logistic regression. Results 1506 patients were evaluated, of which 525 received appropriate HBV vaccination and were assessed for response. Among those, 79% were vaccine responders and 21% were nonresponders. On multivariate analysis, cirrhosis was associated with lower response to the vaccine (OR 0.6, CI 0.44–0.94). We found no significant differences for vaccine response in relation to smoking (87% vs 86%), IV drug abuse (74% vs 72%), Diabetes Mellitus (26% vs 22%) being on hemodialysis (2% vs.5%), or virus related variables. Conclusion HCV infection seems to impair HBV vaccine response, with cirrhosis being the only identifiable risk factor for hypo-responsiveness among studied clinical and virus-related variables.",

keywords = "Female, Hepatitis B virus/immunology, Hepatitis C, Chronic/prevention & control, Humans, Life Style, Male, Middle Aged, Treatment Outcome, Vaccination",

author = "Ashhab, {Ashraf A.} and Holly Rodin and Marilia Campos and Ahmad Abu-Sulb and Hall, {Jane A.} and Jesse Powell and Debes, {Jose D.}",

note = "Funding Information: JD is supported by the Robert Wood Johnson Foundation, Harold Amos Medical Faculty Development Program(AMFDP) and National Institute of Health (NIH) -NCI R21 CA215883-01A1. URLs: Robert Wood Johnson Foundation: www.rwjf.org Harold Amos Medical Faculty Development Program: www.amfdp.org/National institute of health: www.nih.gov The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright: {\textcopyright} 2020 Ashhab et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2020",

month = aug,

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T1 - Response to hepatitis B virus vaccination in individuals with chronic hepatitis C virus infection

AU - Ashhab, Ashraf A.

AU - Rodin, Holly

AU - Campos, Marilia

AU - Abu-Sulb, Ahmad

AU - Hall, Jane A.

AU - Powell, Jesse

AU - Debes, Jose D.

N1 - Funding Information: JD is supported by the Robert Wood Johnson Foundation, Harold Amos Medical Faculty Development Program(AMFDP) and National Institute of Health (NIH) -NCI R21 CA215883-01A1. URLs: Robert Wood Johnson Foundation: www.rwjf.org Harold Amos Medical Faculty Development Program: www.amfdp.org/National institute of health: www.nih.gov The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright: © 2020 Ashhab et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2020/8

Y1 - 2020/8

N2 - Background Previous reports show conflicting results regarding hepatitis B virus (HBV) vaccine efficacy in Hepatitis C virus (HCV)-infected individuals. Aims To evaluate HBV-vaccine response and identify possible factors that may contribute to lower vaccine efficacy in patients infected with HCV. Methods We retrospectively evaluated all patients with chronic HCV infection at Hennepin County Medical Center, in Minneapolis, Minnesota, between 2002 and 2018. We addressed laboratory, liver-related, virus-related as well as vaccine-related variables, and their association to HBV vaccine response. Differences were tested using either a Chi-squared test or a T test to compare means between the two populations. Multivariate regression was modeled as a logistic regression. Results 1506 patients were evaluated, of which 525 received appropriate HBV vaccination and were assessed for response. Among those, 79% were vaccine responders and 21% were nonresponders. On multivariate analysis, cirrhosis was associated with lower response to the vaccine (OR 0.6, CI 0.44–0.94). We found no significant differences for vaccine response in relation to smoking (87% vs 86%), IV drug abuse (74% vs 72%), Diabetes Mellitus (26% vs 22%) being on hemodialysis (2% vs.5%), or virus related variables. Conclusion HCV infection seems to impair HBV vaccine response, with cirrhosis being the only identifiable risk factor for hypo-responsiveness among studied clinical and virus-related variables.

AB - Background Previous reports show conflicting results regarding hepatitis B virus (HBV) vaccine efficacy in Hepatitis C virus (HCV)-infected individuals. Aims To evaluate HBV-vaccine response and identify possible factors that may contribute to lower vaccine efficacy in patients infected with HCV. Methods We retrospectively evaluated all patients with chronic HCV infection at Hennepin County Medical Center, in Minneapolis, Minnesota, between 2002 and 2018. We addressed laboratory, liver-related, virus-related as well as vaccine-related variables, and their association to HBV vaccine response. Differences were tested using either a Chi-squared test or a T test to compare means between the two populations. Multivariate regression was modeled as a logistic regression. Results 1506 patients were evaluated, of which 525 received appropriate HBV vaccination and were assessed for response. Among those, 79% were vaccine responders and 21% were nonresponders. On multivariate analysis, cirrhosis was associated with lower response to the vaccine (OR 0.6, CI 0.44–0.94). We found no significant differences for vaccine response in relation to smoking (87% vs 86%), IV drug abuse (74% vs 72%), Diabetes Mellitus (26% vs 22%) being on hemodialysis (2% vs.5%), or virus related variables. Conclusion HCV infection seems to impair HBV vaccine response, with cirrhosis being the only identifiable risk factor for hypo-responsiveness among studied clinical and virus-related variables.

KW - Female

KW - Hepatitis B virus/immunology

KW - Hepatitis C, Chronic/prevention & control

KW - Humans

KW - Life Style

KW - Male

KW - Middle Aged

KW - Treatment Outcome

KW - Vaccination

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ER -

Response to hepatitis B virus vaccination in individuals with chronic hepatitis C virus infection

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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