Response of serine antiproteases to growth hormone therapy in growth hormone deficient children

Sarah J Schwarzenberg, Harvey L. Sharp, Esther F. Freier, Steven Seelig

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Growth hormone regulates the hepatic mRNA levels of a1-antitrypsin and two contrapsin-like mRNAs in the rat. To determine whether growth hormone regulates similar serine protease inhibitors in humans, we measured serum a1-antitrypsin, a1-antichymotrypsin, and antithrombin III by radioimmunodiffusion in 16 growth hormone deficient children before and after growth hormone therapy. Of the 19 determinations made, 17/19 showed an increase in a1-antirypsin after administration of growth hormone, 198.6 ± 39.1 mg/dl before growth hormone and 239.4 ± 44 mg/dl after growth hormone (p = 0.005). Specificity of the response for a1-antitrypsin was indicated by the fact that neither arantichymotrypsin or antithrombin III values changed after growth hormone (p = 0.6 and 0.5, respectively). These data are compatible with the hypothesis that growth hormone regulates serine protease inhibitors in humans and suggests that investigation of other members of the serpin gene family might prove fruitful in defining additional growth hormone target genes.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalHormone Research in Paediatrics
Volume31
Issue number5-6
DOIs
StatePublished - Jan 1 1989

Fingerprint

Protease Inhibitors
Serine
Growth Hormone
Therapeutics
Serine Proteinase Inhibitors
Antithrombin III
Serpins
Messenger RNA
Genes
Liver

Keywords

  • Antiprotease
  • Antithrombin III
  • Growth hormone
  • α<inf>1</inf>-antichymotrypsin
  • α<inf>1</inf>-antitrypsin

Cite this

Response of serine antiproteases to growth hormone therapy in growth hormone deficient children. / Schwarzenberg, Sarah J; Sharp, Harvey L.; Freier, Esther F.; Seelig, Steven.

In: Hormone Research in Paediatrics, Vol. 31, No. 5-6, 01.01.1989, p. 221-225.

Research output: Contribution to journalArticle

Schwarzenberg, Sarah J ; Sharp, Harvey L. ; Freier, Esther F. ; Seelig, Steven. / Response of serine antiproteases to growth hormone therapy in growth hormone deficient children. In: Hormone Research in Paediatrics. 1989 ; Vol. 31, No. 5-6. pp. 221-225.
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