Abstract
The response of plasma β-endorphin (ir) to infusions of randomly assigned d-amphetamine (20 mg) and placebo was studied in eight schizophrenic patients. Although there was no statistically significant difference between the response to d-amphetamine and placebo, significant increases in plasma β-endorphin (ir) levels were observed following each infusion. Although heterogeneity in β-endorphin (ir) response was observed, individual differences did not relate to clinical variables such as abnormalities on computed tomography or "process-reactive" distinctions. An excessive β-endorphin response to placebo in schizophrenia is discussed.
Original language | English (US) |
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Pages (from-to) | 171-178 |
Number of pages | 8 |
Journal | Psychiatry Research |
Volume | 7 |
Issue number | 2 |
DOIs | |
State | Published - Oct 1982 |
Keywords
- d-amphetamine
- placebo response
- schizophrenia
- β-Endorphin