Response inhibition in youth undergoing intensive treatment for obsessive compulsive disorder

Christine A. Conelea, Sarah Morris, Nicole McLaughlin, Erin Mamaril, Kristen Benito, Brady Case, Abbe Garcia

Research output: Contribution to journalArticlepeer-review


Response Inhibition (RI) is the ability to suppress behaviors that are inappropriate for a given context. Obsessive-compulsive disorder (OCD) has been associated with impaired RI in adults as measured by the Stop Signal Task (SST). Conflicting results have been found in terms of the relationship between OCD severity and SST performance, and no studies to date have examined the relationship between SST and response to OCD treatment. Also relatively unknown is whether RI performance in OCD is associated with developmental or gender differences. This naturalistic study examined the relationship between SST performance, OCD severity, and OCD treatment response in a pediatric sample undergoing intensive treatment involving exposure and response prevention and medication management (n = 36). The SST and Children's Yale-Brown Obsessive Compulsive Scale (CYBOCS) were administered at admission and program discharge. OCD severity was not significantly related to stop signal reaction time (SSRT) in the whole sample and among subgroups divided by age and gender. Baseline SSRT and SSRT change did not predict CYBOCS change across treatment in the whole sample, but exploratory analyses indicated both were significant predictors among female adolescents. Results suggest there may be developmental gender differences in the relationship between RI and clinical improvement in pediatric OCD.

Original languageEnglish (US)
Article number100764
JournalJournal of Obsessive-Compulsive and Related Disorders
StatePublished - Jan 2023

Bibliographical note

Funding Information:
We acknowledge funding support from the National Institute of Mental Health ( K23MH103617 (CC) and K23MH100607 (NM)).

Publisher Copyright:
© 2022 Elsevier Inc.


  • Obsessive-compulsive disorder
  • Pediatric
  • Response inhibition
  • Stop signal
  • Treatment

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'Response inhibition in youth undergoing intensive treatment for obsessive compulsive disorder'. Together they form a unique fingerprint.

Cite this