Respiratory dendritic cells: Mediators of tolerance and immunity

Ryan A. Langlois; Kevin L. Legge

doi:10.1007/s12026-007-0077-0

Respiratory dendritic cells: Mediators of tolerance and immunity

Ryan A. Langlois, Kevin L. Legge

Microbiology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The respiratory tract is under constant bombardment from both innocuous and pathogenic material. The decision of how to respond to these challenges is mediated by a specialized set of antigen presenting cells within the lungs called dendritic cells (DC). Proper respiratory homeostasis requires that these respiratory DC (rDC) utilize both the local lung inflammatory environment as well as recognition of pathogen-specific patterns to determine whether to maintain homeostasis by either driving tolerance or immunity to the inhaled material. This review will focus on rDC and highlight how rDC regulate tolerance and immunity.

Original language	English (US)
Pages (from-to)	128-145
Number of pages	18
Journal	Immunologic Research
Volume	39
Issue number	1-3
DOIs	https://doi.org/10.1007/s12026-007-0077-0
State	Published - Nov 2007

Bibliographical note

Funding Information:
Acknowledgments We thank Dr. Steven Varga, Jodi McGill, and Michelle Edsen for critical reading of this manuscript. This work was supported by University of Iowa Department of Pathology Startup funds to KLL.

Keywords

Dendritic cells
Lungs
Mucosal immunity
Respiratory pathogens
Tolerance

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abstract = "The respiratory tract is under constant bombardment from both innocuous and pathogenic material. The decision of how to respond to these challenges is mediated by a specialized set of antigen presenting cells within the lungs called dendritic cells (DC). Proper respiratory homeostasis requires that these respiratory DC (rDC) utilize both the local lung inflammatory environment as well as recognition of pathogen-specific patterns to determine whether to maintain homeostasis by either driving tolerance or immunity to the inhaled material. This review will focus on rDC and highlight how rDC regulate tolerance and immunity.",

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AU - Langlois, Ryan A.

AU - Legge, Kevin L.

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N2 - The respiratory tract is under constant bombardment from both innocuous and pathogenic material. The decision of how to respond to these challenges is mediated by a specialized set of antigen presenting cells within the lungs called dendritic cells (DC). Proper respiratory homeostasis requires that these respiratory DC (rDC) utilize both the local lung inflammatory environment as well as recognition of pathogen-specific patterns to determine whether to maintain homeostasis by either driving tolerance or immunity to the inhaled material. This review will focus on rDC and highlight how rDC regulate tolerance and immunity.

AB - The respiratory tract is under constant bombardment from both innocuous and pathogenic material. The decision of how to respond to these challenges is mediated by a specialized set of antigen presenting cells within the lungs called dendritic cells (DC). Proper respiratory homeostasis requires that these respiratory DC (rDC) utilize both the local lung inflammatory environment as well as recognition of pathogen-specific patterns to determine whether to maintain homeostasis by either driving tolerance or immunity to the inhaled material. This review will focus on rDC and highlight how rDC regulate tolerance and immunity.

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KW - Lungs

KW - Mucosal immunity

KW - Respiratory pathogens

KW - Tolerance

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ER -

Respiratory dendritic cells: Mediators of tolerance and immunity

Abstract

Bibliographical note

Keywords

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