Respiratory bacterial vaccines

Edward N. Janoff, David E. Briles, Jeff B Rubins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter reviews the vaccines against four prominent and prototypical respiratory mucosal bacteria-. Corynebacterium diphtheriae, Bordetella pertussis, Haemophilus influenzae, and Streptococcus pneumonia. The chapterhighlights the virulence mechanisms involved in the mucosal infections that form the basis for these immunogenic and clinically efficacious vaccines. S. pneumoniae is the single most common cause of potentially preventable respiratory bacterial disease in children and adults worldwide. Systemic immunization is effective in preventing localized respiratory bacterial infections with C. diphtheriae and B. pertussis and both invasive infections and colonization with H. influenzae. Diphtheria vaccine is directed towards a single but pivotal disease-related toxin. The H. influenzae vaccine is directed towards a single prominent virulence mechanism-the polysaccharide capsule, but towards only one capsule (type b) on a complement-lysis-sensitive gram-negative organism. In contrast, S. pneumoniae has no preeminent single disease-determining toxin, and the efficient killing of this gram-positive complement lysis-resistant organism requires the combination of complement, phagocytic cells, and specific antibody to many capsular polysaccharides.

Original languageEnglish (US)
Title of host publicationMucosal Immunology, Two-Volume Set
PublisherElsevier Inc.
Pages905-921
Number of pages17
ISBN (Print)9780124915435
DOIs
StatePublished - Dec 1 2005

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