Resolution of subretinal fluid with systemic corticosteroid treatment in acute Vogt-Koyanagi-Harada disease

Hossein Nazari, Narsing A. Rao

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background To evaluate the correlation of subretinal fluid height with visual acuity (VA) in patients with acute Vogt-Koyanagi-Harada disease (VKH). Method:s Clinical information, fundus photographs and spectral domain optical coherence tomography scans from sequential visits of patients with acute VKH treated with oral corticosteroids were analysed. Subretinal fluid (SRF) height and retinal thickness were measured at the fovea. The association between VA and SRF height was evaluated by Spearman correlation analysis. Results: A total of 12 eyes from 6 consecutive patients were included. SRF height measured 824±508 mm (range 45-1900 mm) at presentation. SRF height correlated with simultaneously measured VA. Initial SRF height did not correlate with resolution time and final VA. Resolution of SRF was attained in 36±24 days (range 10-80 days). The presence of choroidal folds (eight eyes) and multifocal retinal detachment (eight eyes) at presentation correlated with lower initial VA but not with the interval to SRF resolution or with VA at 3-month follow-up. Conclusions: Serous retinal detachment resolved in 36±24 days in patients with acute VKH treated with oral corticosteroids. SRF height correlates with VA measured at the same time. The initial SRF, no matter how elevated, does not correlate with VA at 3 months after presentation.

Original languageEnglish (US)
Pages (from-to)1410-1414
Number of pages5
JournalBritish Journal of Ophthalmology
Volume96
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

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