Resolution of elevated urine glycosaminoglycans and clinical features of mucopolysaccharidosis after successful treatment of neuroblastoma

Research output: Contribution to journalArticle

Abstract

We report a patient with stage 3 ganglioneuroblastoma who initially presented with clinical and laboratory features consistent with mucopolysaccharidosis including coarse facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level. All mucopolysaccharidosis features resolved following successful treatment of neuroblastoma. High GAG levels have been documented in the pediatric oncology literature, yet not as a potential marker of malignancy or other target for clinical utility. This patient prompts further investigation into the relationship between neuroblastoma and elevated GAG levels.

Original languageEnglish (US)
Pages (from-to)e196-e198
JournalJournal of pediatric hematology/oncology
Volume38
Issue number6
DOIs
StatePublished - Jul 26 2016

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Keywords

  • Glycosaminoglycans
  • Mucopolysaccharidosis
  • Neuroblastoma

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