@inbook{6f88216879d34465a366c59d98ab298f,
title = "Resistance to the induction of mixed chimerism in spontaneously diabetic NOD mice depends on the CD40/CD154 pathway and donor MHC disparity",
abstract = "Blockade of CD40/CD154 pathway has proven effective in promoting the induction of allogeneic mixed chimerism. Using NOD mouse model of human type 1 diabetes, we investigated whether allogeneic mixed chimerism can be induced in prediabetic NOD mice and in spontaneously diabetic NOD mice under nonmyeloablative and irradiation-free conditioning therapy and anti-CD154 mAb as a shortterm posttransplant treatment. We found that spontaneously diabetic NOD mice are more resistant to the induction of allogeneic mixed chimerism than prediabetic NOD mice under our nonmyeloablative and irradiation-free conditioning therapy. This alloresistance in spontaneously diabetic NOD mice is dependent on the CD40/CD154 pathway and donor MHC disparity.",
keywords = "Bone marrow transplantation, CD154, Mixed chimerism, NOD mice, Type 1 diabetes",
author = "Bin Luo and Tao Wu and Yisheng Pan and Hakan Sozen and Jianqiang Hao and Yu Zhang and Sutherland, {David E.R.} and Hering, {Bernhard J.} and Zhiguang Guo",
year = "2007",
month = apr,
doi = "10.1196/annals.1394.015",
language = "English (US)",
isbn = "1573316784",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc",
pages = "94--102",
booktitle = "How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis",
}
