Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

Keyphrases

• Neurotoxicity 100%
• Alpha-synuclein (α-syn) 100%
• Knock-in Mouse Model 100%
• Akt Activation 100%
• Vulnerability 22%
• Null Mice 16%
• Dopaminergic Neurons 11%
• MPP+ Toxicity 11%
• Nigral Dopaminergic Neuron 11%
• Parkinsonian 5%
• Neurodegeneration 5%
• Parkinson's Disease 5%
• Neurodegenerative 5%
• Brain Regions 5%
• Wild Mice 5%
• A53T 5%
• Mechanistic Insight 5%
• Non-associated 5%
• Genetic Abnormalities 5%
• Immunoblot Analysis 5%
• Neurotoxin 5%
• Phosphorylated Akt 5%
• Noradrenergic Neurons 5%
• In Vivo Interaction 5%
• Ventral Midbrain 5%
• Biochemical Abnormalities 5%
• Serotonergic Neurons 5%
• Level Dependence 5%
• Cell Survival Signaling 5%

Biochemistry, Genetics and Molecular Biology

• Knockout Mouse 100%
• Mitochondrial Permeability Transition Pore 100%
• Synuclein 100%
• Mouse 27%
• Dopaminergic 22%
• Genetics 5%
• Wild Type 5%
• Western Blot 5%
• Neurotoxin 5%
• Cell Survival 5%
• Wild Type Mouse 5%

Neuroscience

• Neurotoxicity 100%
• Synuclein 100%
• MPTP 100%
• Dopaminergic Neuron 22%
• In Vivo 11%
• Parkinson's Disease 5%
• Midbrain 5%
• Western Blot 5%
• Cell Survival 5%
• Neurodegeneration 5%
• Neurotoxin 5%